The pituitary adenomas are thought to be mixed somatotroph-lactotroph adenomas with pituitary-specific transcription factor-1 (PIT1) expression ( 2, 6). We now describe the clinical course for the son of a previously described case of X-LAG ( 10, 11). Additionally, we compare the mother and son’s pathology that provides further insight into the tumors of X-LAG. This report follows a patient with familial X-LAG prospectively starting at prenatal diagnosis and affords the unique opportunity to compare clinical courses and histopathology findings. These observations help elucidate the pathophysiology, tumorigenesis, and clinical presentation of pediatric pituitary adenomas.
Case Report and Methods Clinical caseĬlinical, laboratory, and radiological data were collected from the time of the infant’s prenatal diagnosis to his most recent clinic visit.
